Wikipedia
Evofosfamide
Evofosfamide ( INN, USAN; formerly known as TH-302) is an investigational hypoxia-activated prodrug that is in clinical development for cancer treatment. The prodrug is activated only at very low levels of oxygen ( hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia.
Evofosfamide is being evaluated in clinical trials for the treatment of multiple tumor types as a monotherapy and in combination with chemotherapeutic agents and other targeted cancer drugs.
Dec 2015 : two Phase 3 trials fail, Merck will not apply for a license