What is "esmirtazapine"

n. A drug developed to treat insomnia and vasomotor symptoms.

Esmirtazapine (ORG-50,081) is a drug which was under development by Organon for the treatment of insomnia and vasomotor symptoms (e.g., hot flashes) associated with menopause. Esmirtazapine is the (S)-- enantiomer of mirtazapine and possesses similar overall pharmacology, including inverse agonist actions at H and 5-HT receptors and antagonist actions at α-adrenergic receptors. As of March 2010, Merck terminated internal clinical development program for esmirtazapine, for hot flashes and insomnia, for strategic reasons.