n. (context steroid English) An androgenic metabolite of testosterone; used to treat certain breast cancers.
Dihydrotestosterone (commonly abbreviated to DHT), or 5α-dihydrotestosterone (5α-DHT), also known as 5α-androstan-17β-ol-3-one, is a sex steroid and androgen hormone. The enzyme 5α-reductase synthesizes DHT from testosterone in the prostate, testes, hair follicles, and adrenal glands. This enzyme reduces the 4,5 double-bond of the testosterone. Relative to testosterone, DHT is much more potent as an agonist of the androgen receptor.
DHT is also known as androstanolone ( INN) and stanolone ( BAN), and is used clinically under brand names including Anabolex, Anaprotin, Andractim, Androlone, Gelovit, Neoprol, Pesomax, and Stanaprol as an androgen and anabolic steroid. Unlike testosterone and some anabolic steroids, DHT cannot be aromatized, and hence, has no risk of estrogenic side effects such as gynecomastia.
Usage examples of "dihydrotestosterone".
I possess all the secondary sex characteristics of a normal man except one: my inability to synthesize dihydrotestosterone has made me immune to baldness.
For example, prostate cancer tumors grow in the presence of the hormone dihydrotestosterone, which is formed from testosterone.
Genistein indirectly inhibits the production of dihydrotestosterone, stopping prostate cancer in its tracks.
He had received the results of the endocrinological tests performed at Henry Ford Hospital, and so knew of my XY karyotype, my high plasma testosterone levels, and the absence in my blood of dihydrotestosterone.