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The Collaborative International Dictionary
Depopulation

Depopulation \De*pop`u*la"tion\, n. [L. depopulatio pillaging: cf. F. d['e]population depopulation.] The act of depopulating, or condition of being depopulated; destruction or explusion of inhabitants.

The desolation and depopulation [of St.Quentin] were now complete.
--Motley.

Douglas Harper's Etymology Dictionary
depopulation

early 15c.; see de- + population.

Wiktionary
depopulation

n. The act of depopulate or condition of being depopulated; the destruction or expulsion of inhabitants.

WordNet
depopulation

n. the condition of having reduced numbers of inhabitants (or no inhabitants at all)

Usage examples of "depopulation".

This was the landscape of the Highland Clearances, that brutal depopulation of the countryside where crofters had been driven off their land by rich landowners eager to make the easier money that came with rearing Cheviot sheep.

The depopulation of the Congo Free State by the Belgians, the horrible massacres of Chinese by European soldiery during the Pekin expedition, are condoned as a painful but necessary part of the civilising process of the world.

The probable depopulation does make annexation a simple matter, since we don't have to consider a policy change.