What is "connexon"

n. (context biochemistry English) An assembly of six connexins forming a bridge called a gap junction between the cytoplasms of two adjacent cells.

In biology, a connexon, also known as a connexin hemichannel or a pannexin channel, is an assembly of six proteins called connexins that form the pore for a gap junction between the cytoplasm of two adjacent cells. This channel allows for bidirectional flow of ions and signaling molecules. The connexon is the hemichannel supplied by a cell on one side of the junction; two connexons from opposing cells normally come together to form the complete intercellular gap junction channel. However, in some cells, the hemichannel itself is active as a conduit between the cytoplasm and the extracellular space, allowing the transference of ions and small molecules lower than 1-2 KDa. Little is known about this function of connexons besides the new evidence suggesting their key role in intracellular signaling.

Connexons made of the same type of connexins are considered homomeric, while connexons made of differing types of connexins are heteromeric.