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arbaclofen placarbil

n. A prodrug of ''R''-baclofen, formerly under development as a potential treatment for patients with GERD and spasticity due to multiple sclerosis.

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Arbaclofen placarbil

Arbaclofen placarbil ( , also known as XP19986) is a prodrug of R- baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.