Wiktionary
aptiganel
n. A discontinued drug with neuroprotective effects but undesirable side effects.
Wikipedia
Aptiganel
Aptiganel (Cerestat; CNS-1102) was a drug candidate that acted as a noncompetitive NMDA antagonist and that was under development by Cambridge Neuroscience, Inc as a treatment for stroke. It has neuroprotective effects and was researched for potential use in the treatment of stroke, but despite positive results in animal studies, human trials showed limited efficacy, as well as undesirable side effects such as sedation and hallucinations, and clinical development was ultimately not continued.
The drug's failure led to the collapse of Cambridge Neuroscience in 1998 and its eventually sale to CeNeS Pharmaceuticals in 2000.