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Answer for the clue "Ups and downs ", 12 letters:
vicissitudes

Word definitions for vicissitudes in dictionaries

Longman Dictionary of Contemporary English Word definitions in Longman Dictionary of Contemporary English
noun EXAMPLES FROM CORPUS ▪ As we have said, Simon Peter's vicissitudes , as depicted by Anita Mason, can not have been unique. ▪ Cranmer's reputation has suffered various vicissitudes . ▪ It could have shared the owner's adventures and vicissitudes , occupied ...

Wiktionary Word definitions in Wiktionary
n. (plural of vicissitude English)

Wikipedia Word definitions in Wikipedia
Vicissitudes is an album by pianist Barry Harris recorded in 1972 and released on the German MPS label.

Usage examples of vicissitudes.

And if at times these things bent the welded iron of his soul, much more did his far away domestic memories of his young Cape wife and child, tend to bend him still more from the original ruggedness of his nature, and open him still further to those latent influences which, in some honest-hearted men, restrain the gush of dare-devil daring, so often evinced by others in the more perilous vicissitudes of the fishery.

That the vicissitudes of suns and rains, to which the soldiers of Maximin were exposed, (Herodian, l.

The exile, or escape, of the guilty Olympius, reserved him for more vicissitudes of fortune: he experienced the adventures of an obscure and wandering life.

According to the vicissitudes of courage or servitude, of favor or disgrace, Procopius ^12 successively composed the history, the panegyric, and the satire of his own times.

Every art was tried to extort from the people the gold and silver which he scattered with a lavish hand from Persia to France: ^81 his reign was marked by the vicissitudes or rather by the combat, of rapaciousness and avarice, of splendor and poverty.

Our journey lasted two weeks, amid various vicissitudes, and during that time I had the opportunity to know (never enough, I remain convinced) my new master.

My masters at Melk had often told me that it is very difficult for a Northerner to form any clear idea of the religious and political vicissitudes of Italy.

Because it has happened that we accepted fugitives who presented themselves garbed in the habit of the Minorites, and afterward I learned that the various vicissitudes of their life had brought them, for a time, quite close to the Dolcinians.

Not seldom in the rapid vicissitudes of the chase, this natural line, with the maternal end loose, becomes entangled with the hempen one, so that the cub is thereby trapped.

Micawber herself (so long the partner of my various vicissitudes, and a woman of a remarkable lucidity of intellect), is, I am led to consider, incompatible with the functions now devolving on me.