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Answer for the clue "Irritant in poison ivy ", 8 letters:
urushiol

Word definitions for urushiol in dictionaries

Wikipedia Word definitions in Wikipedia
Urushiol is an oily organic allergen found in plants of the family Anacardiaceae , especially Toxicodendron spp. (e.g., poison oak , Lacquer Tree , poison ivy , poison sumac ) and also in parts of the mango tree . In sensitive individuals, urushiol can ...

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Poison \Poi"son\, n. [F. poison, in Old French also, a potion, fr. L. potio a drink, draught, potion, a poisonous draught, fr. potare to drink. See Potable , and cf. Potion .] Any agent which, when introduced into the animal organism, is capable of producing ...

Wiktionary Word definitions in Wiktionary
n. (context organic chemistry English) An oil found in plants of the family ''Anacardiaceae'', causing an allergic skin rash on contact; consists of a variable mixture of several organic compounds.