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Answer for the clue "With single-minded determination ", 10 letters:
inexorably

Word definitions for inexorably in dictionaries

WordNet Word definitions in WordNet
adv. in an inexorable manner; "time marches on inexorably"

Wiktionary Word definitions in Wiktionary
adv. In an inexorable manner; without the possibility of stopping or prevention.

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Inexorably \In*ex"o*ra*bly\, adv. In an inexorable manner; inflexibly. ``Inexorably firm.'' --Thomson.

Usage examples of inexorably.

Then as I hauled inexorably a nose appeared, then a head, then all of the big animal hanging limply by his collar.

It was like flailing in deep water as the riptide drags you inexorably out to sea.

As the night deepened, the planet of Farfara turned inexorably on its axis, and so turned its face to the outward reaches of the galaxy beyond the brilliant Orion Arm.

She gave a slow, steady pull and all the apparent knots in the koli thread came inexorably unraveled, to leave nothing but the straight gold string to link her hands.

The vehicle slid inexorably on the ice and although Mackie released the brakes a moment later it did as much harm as good.

Linton in the carriage that was taking them inexorably toward Montpelier Square.

Theory held that it inexorably affected organic as well as nonorganic computation, from one generation to the next.

The insatiable appetite for metals, minerals, rare earths and other nonrenewable substances increased inexorably.

As internal organs were sutured back together, as muscles were mended, and cells destroyed in the tedious process, Digen, whose only responsibility was to stand perfectly still, pulling on a retractor at a steady rate, drifted on her selyn field inexorably up into hyperconsciousness, snapping rudely back down to duoconsciousness every time Thornton attacked a high selyn-field zone.

Staff tended to clump together to continue their conversations or meetings and the students milled round, refused to clear a way for the fire appliances and tried to head unobtrusively but inexorably for the pub or home.

Twenty paces or so in front of them, another door was falling, inexorably sealing them to an exitless part of the complex.

He saw a flaming torch, grasped in a monstrous hand, thrust inexorably down the gullet of an agonized wretch who writhed in vain against the arms that pinioned him.

The wheel of time was moving inexorably around me, forcing me to look into grooves which one cannot talk about and still remain coherent.

The two gunfighters stood and stared at each other, calm and motionless, as the clock ticked inexorably toward the moment each had been created for.

The steadily melting icecaps had been raising the sea level, slowly, inexorably, a few inches a year.