Tries the patience of

• Succeeds in annoying
• Ruffles the feathers of
• Causes vexation
• Wears on
• Gets on the nerves of
• Exasperates
• Bothers a lot
• Nettles
• Ruffles feathers

Wiktionary Word definitions in Wiktionary
vb. (en-third-person singular of: irk )