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Answer for the clue "Eliminated rough edges ", 10 letters:
smoothened

Word definitions for smoothened in dictionaries

Wikipedia Word definitions in Wikipedia
Smoothened is a protein that in humans is encoded by the SMO gene . Smoothened is not a G protein-coupled receptor (it is instead a GPCR-like receptor) that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the ...

Wiktionary Word definitions in Wiktionary
vb. (en-past of: smoothen )

WordNet Word definitions in WordNet
adj. made smooth by ironing [syn: smoothed ]

Usage examples of smoothened.

But she finally got the 454 big-block engine smoothened out and continued north on Dogwood, then turned west on Cypress and across Little Blackberry Creek.