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Answer for the clue "Reversals of fortune ", 8 letters:
setbacks

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n. (plural of setback English)

Usage examples of setbacks.

And so the superstition fed upon the results, since a house weakened would suffer setbacks, and so seem to be in the disfavor of the gods.

No one had believed it possible, not even after the setbacks America had suffered in the Middle East in late 2005 and early in 2006.

She saw it in the defeats and setbacks America’s military were suffering in the Mid-East, in the Pacific, and in Korea.

As you can imagine, with the setbacks in Turkey and Saudi Arabia, with the continued retreat in South Korea, and now with the shocking capitulation of Japan, other nations ** facing the joint GIR and CAS juggernauts are reluctant to join our alliance.

We have suffered setbacks and I expect we will suffer more before we eventually discover our “Battle of Midway” in this war.

But even while enduring these setbacks, I can report that our young people and their officers and commanders are fighting with a will and resolve that is profound and awe inspiring.

While Mara of the Acoma had humiliated the Anasati early in her rise to greatness, Chumaka had,offered sage counsel that had sheltered family interests from setbacks in the conflict that had followed between the Acoma and the Minwanabi.

And so the superstition fed upon the results, since a house weakened would suffer setbacks, ant so seem to be in the disfavor of the gods.

Campaigns in the field had taught him that setbacks must be faced at once, and overcome, lest enemies gain opening and triumph.

While Mara of the Acoma had humiliated the- Anasati early in her rise to greatness, Chumaka had offered sage counsel that had sheltered family interests from setbacks in the conflict that had followed between the Acoma and the Minwanabi.

Scott’s face that something was wrong—something other than the half-dozen serious setbacks they had suffered in the last hour.

Just as he was sure that no one could dish out setbacks like Captain Kirk.

And considering the numerous setbacks to American interests precipitated by the current administration’s efforts to thwart Zenim, he had thought he was on the verge of realizing that goal.

After so many years of success…after so much territory won…it was hard to take the setbacks and reversals.

Meaning that if she, Jaine, didn't cooperate, any setbacks in Gina's sister's career would be laid directly on her doorstep.