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Answer for the clue "They're released by the immune system ", 10 letters:
histamines

Word definitions for histamines in dictionaries

Wiktionary Word definitions in Wiktionary
n. (plural of histamine English)

Usage examples of histamines.

A swarm of histamines rushed forth to combat the dust mites storming into Bubba's sinuses and lungs as he probed with a flashlight on the floor of his Jeep.