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Answer for the clue "Continual changes ", 8 letters:
fluxions

Word definitions for fluxions in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Fluxions \Flux"ions\, n. pl. (Math.) See Fluxion , 6 (b) .

Wiktionary Word definitions in Wiktionary
n. (context obsolete mathematics English) differential calculus vb. (context geology English) (en-third-person singular of: fluxion)

Usage examples of fluxions.

For those who know how to read between the lines, this is sufficient to prove Newton had the calculus—or Fluxions, as he called it—in ’65, most likely ’64.

But before the trees had blossomed for the fourth time since Baudolino had met him, Otto was reduced to a shadow of himself by malarial fevers, pains in all his joints, fluxions of the chest, not to mention gallstone.