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Answer for the clue "Roman philosopher whose work "De Officiis" was the second printed book (after the Gutenberg Bible) ", 4 letters:
ciro

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Wikipedia Word definitions in Wikipedia
Cirò can refer to: Cirò, Calabria , Italian comune in the province of Crotone Cirò Marina , Italian comune in the province of Crotone Cirò (wine) , wine made in the environs of Cirò