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Answer for the clue "L.A. lost it to Chi. in 2005 ", 4 letters:
alcs

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Wiktionary Word definitions in Wiktionary
n. 1 (context baseball English) The http://en.wikipedia.org/wiki/American%20League%20Championship%20Series, a best of seven game series played to determine the champion of the American League. 2 Altria Corporate Services, Inc., a wholly owned subsidiary ...

Wikipedia Word definitions in Wikipedia
ACLS commonly refers to the American League Championship Series in American baseball ALCS may also refer to: Abundant Life Christian School , a K4-12 school in Madison, Wisconsin ALCS transaction monitor , an IBM mainframe transaction processing monitor ...