Part of it is on L.I

• City where BHO graduated from college
• Where JFK is
• Brooklyn loc
• Home of Times Sq. and Columbus Cir.
• S.I. is part of it
• Wall St. location
• Madison Ave. locale
• Big Apple, briefly
• Song from 65-Across that's hidden in 20- and 54-Across and 10- and 35-Down

Wiktionary Word definitions in Wiktionary
a. (context nonstandard English) nice