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Answer for the clue "Rarely used antonym of harmless ", 7 letters:
nocuous

Word definitions for nocuous in dictionaries

Wiktionary Word definitions in Wiktionary
a. Likely to cause harm or damage

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Nocuous \Noc"u*ous\, a. [L. nocuus, fr. nocere to hurt.] Hurtful; noxious. [R.] -- Noc"u*ous*ly , adv. [R.]

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1630s, "noxious, harmful," from Latin nocuus "harmful," from stem of nocere "to hurt, injure, harm" (see innocuous ).

Usage examples of nocuous.

Hassem had most likely purchased blossoms that were cut or plucked improperly, and therefore had lost some of their nocuous powers.