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Alternative clues for the word mdi

• When Michelangelo began "David"
• Early 16th-century date
• 1501, on a monument
• Start of the 16th century
• (LXXX - I) x (XX - I)
• Year in Pope Alexander VI's reign
• Year of an Amerigo Vespucci voyage
• Year that Michelangelo began work on "David"
• IX years after Columbus's voyage
• 16th-century start