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Answer for the clue "Business-district thoroughfare, often ", 10 letters:
mainstreet

Alternative clues for the word mainstreet

Word definitions for mainstreet in dictionaries

Wikipedia Word definitions in Wikipedia
" Mainstreet " is a song written and recorded by Bob Seger & The Silver Bullet Band . It was released in April 1977 as the fourth single from the album Night Moves . The song peaked at number 24 on the U.S. Billboard Hot 100 and has since become a staple ...

Usage examples of mainstreet.

Twelve-hundred pound moose walk down the mainstreet in Brattleboro, Vermont.