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Answer for the clue "Tied in factories with change leading to a loss of living things ", 15 letters:
desertification

Alternative clues for the word desertification

Word definitions for desertification in dictionaries

Longman Dictionary of Contemporary English Word definitions in Longman Dictionary of Contemporary English
noun EXAMPLES FROM CORPUS ▪ Farming is leading to the desertification of large areas of the planet. ▪ If desertification continues to spread, the dust bowl will not only undermine the economy but also trigger a huge migration eastward. ▪ In many instances ...

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1973, from desert (n.1) + -fication . In French, désertisation is attested from 1968.

WordNet Word definitions in WordNet
n. the gradual transformation of habitable land into desert; is usually caused by climate change or by destructive use of the land; "the dust storms in Korea are the result of rapid desertification in China"

Wiktionary Word definitions in Wiktionary
n. Process by which a geographic region becomes a desert. The change may result from natural changes in climate or by human activity.

Wikipedia Word definitions in Wikipedia
Desertification is a type of land degradation in which a relatively dry land region becomes increasingly arid, typically losing its bodies of water as well as vegetation and wildlife. It is caused by a variety of factors, such as climate change and human ...

Usage examples of desertification.

Forests shrank, grasslands spread, and desertification intensified once more.