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Answer for the clue "Destroyed nicotine, protecting hearts at risk ", 11 letters:
on thin ice

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Wikipedia Word definitions in Wikipedia
On Thin Ice is a documentary following a team of three consisting of Ben Fogle , James Cracknell , and Ed Coats in their race across Antarctica to the South Pole . The series covers the whole experience, beginning with training efforts in Switzerland and ...

Wiktionary Word definitions in Wiktionary
a. (context idiomatic English) In a dangerous, hazardous, or delicate situation; at risk.