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Answer for the clue "Doctor foretold extremes of Holmes' life in novel ", 17 letters:
lord of the flies

Word definitions for lord of the flies in dictionaries

Wikipedia Word definitions in Wikipedia
Lord of the Flies is a 1954 novel by Nobel Prize -winning English author William Golding about a group of British boys stuck on an uninhabited island who try to govern themselves with disastrous results.

Wiktionary Word definitions in Wiktionary
n. (context idiomatic biblical English) a ruler over a worthless kingdom; leader of a meaningless microcosm.