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Answer for the clue "Doctor foretold extremes of Holmes' life in novel ", 17 letters:
lord of the flies

Word definitions for lord of the flies in dictionaries

Wikipedia Word definitions in Wikipedia
" Lord of the Flies " is the fifth episode of the ninth season of the science fiction television series The X-Files , and the show's 187th episode overall. It first premiered on the Fox network in the United States on December 16, 2001, and was subsequently ...

Wiktionary Word definitions in Wiktionary
n. (context idiomatic biblical English) a ruler over a worthless kingdom; leader of a meaningless microcosm.