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Answer for the clue "Post Office New York state’s used for letter delivery system once ", 12 letters:
pony express

Word definitions for pony express in dictionaries

WordNet Word definitions in WordNet
n. express mail carried by relays of riders on horseback; especially between Missouri and California around 1860

Wikipedia Word definitions in Wikipedia
The Pony Express was a mail service delivering messages, newspapers, mail, and small packages from St. Joseph, Missouri , across the Great Plains , over the Rocky Mountains and the Sierra Nevada to Sacramento, California , by horseback, using a series of ...