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Answer for the clue "Risk that could make Joe despair ", 10 letters:
jeopardise

Word definitions for jeopardise in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
chiefly British English spelling of jeopardize ; for suffix, see -ize . Related: Jeopardised ; jeopardising .

Wiktionary Word definitions in Wiktionary
vb. (standard spelling of from=non-Oxford British spelling jeopardize English)

WordNet Word definitions in WordNet
v. pose a threat to; present a danger to; "The pollution is endangering the crops" [syn: endanger , jeopardize , menace , threaten , imperil , peril ]

Usage examples of jeopardise.

And I am hither come for sake of a poor Fool that is braver than the bravest--one did jeopardise his foolish life for sake of a maid, wherefore I, Hugo, do give him life.

A kidnapping by militants, particularly the kidnapping of such a prestigious refugee, would severely jeopardise our position.

She did not wish to do anything which might jeopardise her time with her father.

It was true, as her solicitor had warned her only this morning, that a bad summer, a freak thunder storm, anything, in fact, that damaged her flower- crop, could jeopardise her financial position almost disastrously.

All this he knew would be jeopardised if he once more dropped into the social position of the husband of Mrs.

I did point out to you the risks we were taking, and I did warn you, as well, that there was no way I was going to allow my reputation professional or personal to be jeopardised by this marriage.

To make her see that what they felt for one another was too precious, too important to be jeopardised by any kind of misunderstanding.

I suppose they can get their kicks without jeopardising their vows of celibacy.

No point in jeopardising the child's future by antagonising her benefactors.