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Answer for the clue "Start off initially in drug trial with least sense ", 8 letters:
pottiest

Word definitions for pottiest in dictionaries

Wiktionary Word definitions in Wiktionary
a. (en-superlativepotty)

WordNet Word definitions in WordNet
adj. (British informal) trivial; "potty little details" very drunk [syn: besotted , blind drunk , blotto , crocked , cockeyed , fuddled , loaded , pie-eyed , pissed , pixilated , plastered , slopped , sloshed , smashed , soaked , soused , sozzled , squiffy ...