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Answer for the clue "American about to upset excellent doctor showing heartlessness ", 7 letters:
acardia

Alternative clues for the word acardia

Word definitions for acardia in dictionaries

Wiktionary Word definitions in Wiktionary
n. A birth defect in which the heart is absent

WordNet Word definitions in WordNet
n. congenital absence of the heart (as in the development of some monsters)