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Answer for the clue "Major blood vessel in the neck ", 12 letters:
jugular vein

Word definitions for jugular vein in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Jugular \Ju"gu*lar\, n. [Cf. F. jugulaire. See Jugular , a.] (Anat.) One of the large veins which return the blood from the head to the heart through two chief trunks, an external and an internal, on each side of the neck; -- called also the jugular vein ...

Wikipedia Word definitions in Wikipedia
The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava .

WordNet Word definitions in WordNet
n. veins in the neck that return blood from the head [syn: vena jugularis , jugular ]

Wiktionary Word definitions in Wiktionary
n. (context anatomy English) Any of several veins on each side of the neck, which drain the brain, face and neck of deoxygenated blood.