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Answer for the clue "Most irritable clergyman grasps 1 + 100 + 1000 + 50 ", 10 letters:
prickliest

Word definitions for prickliest in dictionaries

Wiktionary Word definitions in Wiktionary
a. (en-superlative of: prickly )

WordNet Word definitions in WordNet
adj. very irritable; "bristly exchanges between the White House and the press"; "he became prickly and spiteful"; "witty and waspish about his colleagues" [syn: bristly , splenetic , waspish ] having or covered with protective barbs or quills or spines ...

Usage examples of prickliest.

Underville was probably the prickliest creature here, but even she wasn’t big on formalities.

He made a leap for the prickliest portion of the cactus, grimacing in half-expectation of a crotchful of needles.