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Answer for the clue "Tosspot's sickness", 10 letters:
crapulence

Alternative clues for the word crapulence

The act of drinking alcoholic beverages to excess

Overindulgence

Word definitions for crapulence in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Crapulence \Crap"u*lence\ (-?-lens), n. The sickness occasioned by intemperance; surfeit. --Bailey.

Wiktionary Word definitions in Wiktionary
n. 1 sickness or indisposition caused by excessive eating or drinking 2 intemperance; debauchery; excessive indulgence

WordNet Word definitions in WordNet
n. the act of drinking alcoholic beverages to excess; "drink was his downfall" [syn: drink , drinking , boozing , drunkenness ]

Usage examples of crapulence.

Alcohol crapulence clogs perception, but drug crapulence flays it, and by now the kitchen was a noisome feast for peeled senses.

There's nothing to stop you from associating with my servants if you want to, but I'd prefer not to have the younger ones reduced to a state of crapulence for your purposes.