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Alternative clues for the word painintheneck

• Big bother
• Really annoying person
• "___ is a sign of discomfort just below your head"
• Persistently difficult person or thing (caused by a whiplash?)
• "That awful chiropractor is a..."
• Result of an encounter wi
• Very annoying person
• Result of an encounter with 52-Across?
• Troublesome person or thing