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Answer for the clue "Discomfort ", 7 letters:
misease

Word definitions for misease in dictionaries

Wiktionary Word definitions in Wiktionary
n. (label en archaic) suffering, distress.

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Misease \Mis*ease"\, n. [OE. mesaise, OF. mesaise.] Want of ease; discomfort; misery. [Obs.] --Chaucer.

Usage examples of misease.

And moreover, the misease of hell shall be in default of meat and drink.