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Two-letter combinations
Answer for the clue "Two-letter combinations ", 7 letters:
bigrams
Word definitions for bigrams in dictionaries
Wiktionary
Word definitions in Wiktionary
n. (plural of bigram English)
Usage examples of bigrams.
Once I let my nose follow that clue, I started noticing other bigrams also corresponded to presidential initials.
And again, this presupposes that the would-be code breaker could recognize the bigrams, the nulls, the pattern in general.