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Answer for the clue ""Life ___ end in itself . . . ": O. W. Holmes ", 4 letters:
isan

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Wikipedia Word definitions in Wikipedia
Isan , or ISAN , may refer to: Isan , a region of Thailand Isan people Isan language , the collective name for the dialects of the Lao language as they are spoken in Thailand Isan , a dialect of the Yopno language International Standard Audiovisual Number ...