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Answer for the clue "Sedates ", 12 letters:
tranquilizes

Word definitions for tranquilizes in dictionaries

Wiktionary Word definitions in Wiktionary
vb. (en-third-person singular of: tranquilize)

Usage examples of tranquilizes.

In name of God, how it tries that it tranquilizes to me when you are seated there, aiming to me with a weapon?