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Answer for the clue "An acquired skin disease characterized by patches of unpigmented skin (often surrounded by a heavily pigmented border) ", 8 letters:
vitiligo

Word definitions for vitiligo in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Vitiligo \Vit`i*li"go\, n. [L., a kind of tetter, fr. vitium blemish, vice.] (Med.) A rare skin disease consisting in the development of smooth, milk-white spots upon various parts of the body.

Wikipedia Word definitions in Wikipedia
Vitiligo is the debut album from rapper & singer Krizz Kaliko . His debut album comes after spending several years lending his voice to releases from Tech N9ne and his other labelmates. The album's title comes from the skin disorder that Krizz suffers from, ...

WordNet Word definitions in WordNet
n. an acquired skin disease characterized by patches of unpigmented skin (often surrounded by a heavily pigmented border)

Wiktionary Word definitions in Wiktionary
n. 1 The patchy loss of skin pigmentation. 2 (context obsolete English) alphos, a form of leprosy.

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1650s, from Latin vitiglio "a kind of cutaneous eruption, tetter" (Celsus), perhaps with an original sense of "blemish," from PIE *wi-tu- , from root *wei- (3) "vice, fault, guilt" (see vice (n.1)).

Usage examples of vitiligo.

I recognized, or thought I did, a patch of vitiligo on the man's forehead.

Except for the patch of vitiligo on his forehead which had turned from pink to almost white, there was no evidence of fear in his face.