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Answer for the clue "The quality of being unhealthful and generally bad for you ", 15 letters:
unwholesomeness

Word definitions for unwholesomeness in dictionaries

Wiktionary Word definitions in Wiktionary
n. The state or quality of being unwholesome.

WordNet Word definitions in WordNet
n. the quality of being unhealthful and generally bad for you [syn: morbidness , morbidity ] [ant: wholesomeness ]

Usage examples of unwholesomeness.

Indeed the lower classes were inclined to picture them as monsters of unwholesomeness and perversion, potential murderers of little children and celebrants of various equivalents of the Black Mass.

But around them, beneath them, above them, an ancient unwholesomeness stirred.