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Answer for the clue "Syndrome resulting from a serious acute (sometimes fatal) infection associated with the presence of staphylococcus ", 3 letters:
tss

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The IBM Time Sharing System TSS/360 is a discontinued early time-sharing operating system designed exclusively for a special model of the System/360 line of mainframes, the Model 67 . Made available on a trial basis to a limited set of customers in 1967, ...