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Answer for the clue "An antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain ", 9 letters:
tricyclic

Word definitions for tricyclic in dictionaries

Wikipedia Word definitions in Wikipedia
Tricyclics are chemical compounds that contain three interconnected rings of atoms . Many compounds have a tricyclic structure, but in pharmacology , the term has traditionally been reserved to describe heterocyclic drugs. Among these are antidepressants ...

WordNet Word definitions in WordNet
n. an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain [syn: tricyclic antidepressant , tricyclic antidepressant drug ]

Wiktionary Word definitions in Wiktionary
a. (context chemistry English) Having three rings of atoms in the molecule. n. (context chemistry English) Any tricyclic compound.

Usage examples of tricyclic.

If Richard had listened to me in the first place and had her committed, they could’ve put her on a good tricyclic and she might be alive today and the kids could’ve been spared all the shit they went through.