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Answer for the clue "A operation that removes a circular section of bone from the skull ", 12 letters:
trephination

Word definitions for trephination in dictionaries

WordNet Word definitions in WordNet
n. a operation that removes a circular section of bone from the skull

Wiktionary Word definitions in Wiktionary
n. the surgical procedure in which a hole is drilled in the skull and a circular piece of bone removed

Usage examples of trephination.

Unlike many other ancient cultures, the Egyptians of the Smith Papyrus did not use trephination in the treatment of skull injuries.

The ancient Egyptians and the Incas had performed skull trephinations, opening holes in the cranium with only the crudest of tools and no thought of sterile technique.

There was a computer graphic showing which of her three tumors they had biopsied and the location of the trephination, of the skull just above the right ear.