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Answer for the clue "An abnormal enlargement of the spleen ", 12 letters:
splenomegaly

Word definitions for splenomegaly in dictionaries

WordNet Word definitions in WordNet
n. an abnormal enlargement of the spleen

Wiktionary Word definitions in Wiktionary
n. (context pathology English) An enlargement of the spleen.

Wikipedia Word definitions in Wikipedia
Splenomegaly is an enlargement of the spleen . The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen . Splenomegaly is one of the four cardinal signs of hypersplenism which include; some reduction in the number of circulating blood ...

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
enlargement of the spleen, 1900, from spleno- + Greek megas "great" (fem. megale ; see mickle ).