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Answer for the clue "An abnormal enlargement of the spleen ", 12 letters:
splenomegaly

Word definitions for splenomegaly in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
enlargement of the spleen, 1900, from spleno- + Greek megas "great" (fem. megale ; see mickle ).

WordNet Word definitions in WordNet
n. an abnormal enlargement of the spleen

Wikipedia Word definitions in Wikipedia
Splenomegaly is an enlargement of the spleen . The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen . Splenomegaly is one of the four cardinal signs of hypersplenism which include; some reduction in the number of circulating blood ...

Wiktionary Word definitions in Wiktionary
n. (context pathology English) An enlargement of the spleen.