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Answer for the clue "Paralysis of both arms and both legs ", 12 letters:
quadriplegia

Word definitions for quadriplegia in dictionaries

Wiktionary Word definitions in Wiktionary
n. 1 paralysis from the neck down 2 paralysis of all four limbs

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1895, a medical hybrid coined from Latin-based quadri- "four" + -plegia , as in paraplegia , ultimately from Greek plege "stroke," from root of plessein "to strike" (see plague (n.)). A correct, all-Greek formation would be *tessaraplegia .

WordNet Word definitions in WordNet
n. paralysis of both arms and both legs

Usage examples of quadriplegia.

Thom knew enough about quadriplegia to be a doctor and had learned enough forensics from Lincoln Rhyme to be a detective.

Grinspoon told him the defendant was one of thousands of people who claim that marijuana is the best thing they can find for controlling the kind of painful spasms associated with quadriplegia, multiple sclerosis, and traumatic nerve injury.