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Answer for the clue "A degenerative state of the cell nucleus ", 8 letters:
pyknosis

Word definitions for pyknosis in dictionaries

WordNet Word definitions in WordNet
n. a degenerative state of the cell nucleus [syn: pycnosis ]

Wiktionary Word definitions in Wiktionary
n. In biology, shrinkage and condensing, such as that of a dying cell or the appearance of a cell's nucleus.

Wikipedia Word definitions in Wikipedia
Pyknosis , or karyopyknosis , is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis . It is followed by karyorrhexis , or fragmentation of the nucleus. Pyknosis (from Greek pyknono meaning "to thicken up, ...