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Answer for the clue "A rare abnormality marked by premature aging (gray hair and wrinkled skin and stooped posture) in a child ", 8 letters:
progeria

Word definitions for progeria in dictionaries

WordNet Word definitions in WordNet
n. a rare abnormality marked by premature aging (gray hair and wrinkled skin and stooped posture) in a child

Wikipedia Word definitions in Wikipedia
Progeria ( Hutchinson–Gilford progeria syndrome , HGPS , progeria syndrome ) is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes . The word ...

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
1902, Modern Latin, from Greek progeros "prematurely old;" from pro- (see pro- ) + geras "old man" (see geriatric ) + abstract noun ending -ia .

Wiktionary Word definitions in Wiktionary
n. (context pathology English) An extremely rare genetic condition wherein symptoms resembling aspects of age are manifested at an early age.

Usage examples of progeria.

The coincidence of so many victims of progeria provided a major boost in research on the disease, culminating in a major conference at Berkeley at which several important papers were delivered.

Lydia had encountered reports of such progeria dating from the sixteenth century, and was of the opinion that some unknown vitamin deficiency or breakdown was responsible.

It looked like a mini-human with progeria, like a six inch mutant Uncle Fester.

Kids passing progeria around, picking up communicative old age as easily as croup.

Lovely Jenine lying there, aging decades within days from the progeria plague epidemic, youth sucked from her by a viral time machine.