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Answer for the clue "Pain in the rectum ", 10 letters:
proctalgia

Word definitions for proctalgia in dictionaries

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"pain in the ass," 1811, from medical Latin proct- , Latinized form of Greek comb. form of proktos "anus" (see proctology ) + -algia .

WordNet Word definitions in WordNet
n. pain in the rectum