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Answer for the clue "Pain in the rectum ", 10 letters:
proctalgia

Word definitions for proctalgia in dictionaries

WordNet Word definitions in WordNet
n. pain in the rectum

Douglas Harper's Etymology Dictionary Word definitions in Douglas Harper's Etymology Dictionary
"pain in the ass," 1811, from medical Latin proct- , Latinized form of Greek comb. form of proktos "anus" (see proctology ) + -algia .