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Answer for the clue "Congenital defect of having one or more extra chromosomes in somatic cells ", 8 letters:
polysomy

Word definitions for polysomy in dictionaries

Wiktionary Word definitions in Wiktionary
n. The condition of being polysomic

WordNet Word definitions in WordNet
n. congenital defect of having one or more extra chromosomes in somatic cells

Wikipedia Word definitions in Wikipedia
Polysomy is a condition found in many species, including fungi, plants, insects, and mammals, in which an organism has at least one more chromosome than normal, i.e., there may be three or more copies of the chromosome rather than the expected two copies. ...