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Answer for the clue "The exertion of so much effort that discomfort or injury results ", 12 letters:
overexertion

Alternative clues for the word overexertion

Word definitions for overexertion in dictionaries

The Collaborative International Dictionary Word definitions in The Collaborative International Dictionary
Overexertion \O"ver*ex*er"tion\, n. Excessive exertion; as, he strained his back from overexertion.

Wiktionary Word definitions in Wiktionary
n. excessive exertion; so much exertion that discomfort or injury results

WordNet Word definitions in WordNet
n. excessive exertion; so much exertion that discomfort or injury results

Usage examples of overexertion.

The doctor, who remembered the extreme danger of any overexertion in such cases, hardly allowed him to lift his head from the pillow.

Essie announced firmly that if I was determined to kill self with overexertion she was at least going to stay up to enjoy spectacle, and as soon as she was gently snoring on the couch I called Albert again.

To his chagrin, he knew the overexertion of his lungs had nothing to do with physical labor.

Overexertion is killing him slowly be-cause he won't give in when he feels tired.

Overexertion is killing him slowly because he won't give in when he feels tired.

I intend to die at the age of one hundred years or more, in a soft bed of overexertions with a young and willing doxie, not with a gutful of sharp steel or on the horns of some wild bull, thank you.

And once she properly recovered from her overexertions she should be right fine.

Or had his long sequence of overexertions and relapses aggravated the damage enough to cripple him?

On the list of overexertions which his doctor had ordered him to avoid, climbing stairs had stood first, underlined in red ink, ahead even of "excessive sexual activity.