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Answer for the clue "The act of rendering optimal ", 12 letters:
optimisation

Word definitions for optimisation in dictionaries

WordNet Word definitions in WordNet
n. the act of rendering optimal; "the simultaneous optimization of growth and profitability"; "in an optimization problem we seek values of the variables that lead to an optimal value of the function that is to be optimized"; "to promote the optimization ...

Wiktionary Word definitions in Wiktionary
n. (alternative spelling of optimization English)

Usage examples of optimisation.

Yatakangi optimisation programme as quote a barefaced lie unquote.