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Answer for the clue "Syphilis of the central nervous system ", 13 letters:
neurosyphilis

Word definitions for neurosyphilis in dictionaries

Wikipedia Word definitions in Wikipedia
Neurosyphilis is an infection of the brain or spinal cord caused by the spirochete Treponema pallidum . It usually occurs in people who have had chronic, untreated syphilis , usually about 10 to 20 years after first infection and develops in about 25%–40% ...

Wiktionary Word definitions in Wiktionary
n. (context pathology English) A syphilis infection affecting the nervous system.

WordNet Word definitions in WordNet
n. syphilis of the central nervous system

Usage examples of neurosyphilis.

With the neurosyphilis gradually eroding his rationality he emerged from the ranks of his contemporaries as the most ruthless, the most successful, and the most feared gang boss of them all.

In his latter years, with the neurosyphilis raging in his head, he lost all grip on reality, seeing visions and hearing voices.